Chain reaction: LINC complexes and nuclear positioning
نویسندگان
چکیده
منابع مشابه
Structural insights into LINC complexes.
Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH)-peptide bearing proteins residing in the oute...
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It has long been observed that many neuronal types position their nuclei within restricted cytoplasmic boundaries. A striking example is the apical localization of cone photoreceptors nuclei at the outer edge of the outer nuclear layer of mammalian retinas. Yet, little is known about how such nuclear spatial confinement is achieved and further maintained. Linkers of the Nucleoskeleton to the Cy...
متن کاملNuclear envelopathies: a complex LINC between nuclear envelope and pathology
Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components. These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear membrane (ONM), such as Nesprins, or...
متن کاملExploring the LINC to nuclear envelope spacing
L INC complexes do not maintain the space between nuclear membranes, except in cells exposed to mechanical stress, Cain et al. reveal. SUN proteins in the inner nuclear membrane and KASH proteins in the outer nuclear membrane form LINC complexes that regulate multiple processes by connecting the nucleoskeleton to the cytoskeleton. LINC complexes are also thought to maintain a uniform gap of ~50...
متن کاملAn unresolved LINC in the nuclear envelope.
The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architec...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2019
ISSN: 2046-1402
DOI: 10.12688/f1000research.16877.1